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During tumor progres-sion however, TGF-beta signaling may switch to a pro-metastatic role through mecha-nisms that are not fully understood

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341Index...................................................................... In older children, the growth plate may conversely act as a barrier to spread ofinfection in the joint

In older children, the growth plate may conversely act as a barrier to spread ofinfection in the joint. Onsetof action is less than 3 min, and recovery occurswithin 30–40 min. It was sug-gested that it also may induce renal failure as adrug-related complication (Adhikari et al. All qEEG parameters were better in thehypothermia-treated group, but the differences did not reach statistical significance

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